THE HUMAN MICROBIOME-DERIVED ANTIMICROBIAL LUGDUNIN SELF-REGULATES ITS BIOSYNTHESIS BY A FEED-FORWARD MECHANISM

The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism

ABSTRACT Many human microbiome members inhibit bacterial competitors by production of antimicrobial compounds whose expression needs to be tightly controlled to balance the costs and benefits of compound biosynthesis.The nasal commensal Staphylococcus lugdunensis outcompetes Staphylococcus aureus using the antimicrobial lugdunin.The lugdunin biosyn

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HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

BackgroundIt is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure.As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started prophylactic ART an estimated 10 days (Participant A; 54-year-old male) and 12 days (Participant B; 31-y

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Discovery of essential fatty acids

Dietary fat was recognized as a good source of energy and fat-soluble vitamins by the first part of the 20th century, but fatty acids were Cars not considered to be essential nutrients because they could be synthesized from dietary carbohydrate.This well-established view was challenged in 1929 by George and Mildred Burr who reported that dietary fa

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Survey on the search of Internet of Things

With the popularization and development of the Internet of Things,the search of Internet of Things urgently needs to be solved in academia and industry and becomes a hot research topic.With Allen Wrench the increasing data generated by sensors,only the search of IoT makes this data valuable.However,different from the traditional Internet search eng

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